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Murugan, V.
- Simultaneous Estimation of Paracetamol and Zaltoprofen in Pharmaceutical Dosage Form by HPTLC
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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, IN
2 Lotus Labs, Vasanth Nagar, Bengaluru, IN
1 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, IN
2 Lotus Labs, Vasanth Nagar, Bengaluru, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2075-2078Abstract
Objective: A method for HPTLC was developed and validated for simultaneous estimation of Paracetamol and Zaltoprofen in a pharmaceutical dosage form. Methods: The Chromatographic separation was achieved on TLC aluminum plates precoated with silica gel G60 F254 as the stationary phase. The mobile phase consisted of Hexane: Chloroform: Methanol in the ratio of 3.5:5.5:1v/v/v. Results: The method was found to be linear in the concentration range of 0.8-4μg/spot for PCM and 0.2-1 μg/spot for ZLT and the correlation coefficient were found to be 0.996 for PCM and 0.998 for ZLT. The %RSD value obtained for intraday precision were 0.237 and 0.377 and for inter-day precision were 0.259 and 0.766 respectively, the low % RSD indicates that proposed method is precise as per ICH guidelines. The accuracy of the method was determined and the mean recovery of PCM was 99.73-100.15% and ZLT was 99.57-100.18%. LOD and LOQ values were found to be 0.034 μg/spot and 0.105 μg/spot for PCM, 0.006μg/spot and 0.018 μg/spot for ZLT. Conclusion: The method reported is accurate, precise, specific, robust and linear for the estimation of Paracetamol and Zaltoprofen in Pharmaceutical dosage form.Keywords
Paracetamol, Zaltoprofen, HPTLC, Chromatography, HPTLC.References
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- Implementation of Quality by Design Approach for Method Development and Validation: A Review
Abstract Views :82 |
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Authors
Affiliations
1 Research Scholar, College Of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore-560078,, IN
2 Associate Professor, College of Pharmaceutical Sciences, Dayanandasagar University, Bengaluru-560078, IN
3 Professor and Dean, College of Pharmaceutical Sciences, Dayanandasagar University, Bengaluru-560078,, IN
1 Research Scholar, College Of Pharmaceutical Sciences, Dayananda Sagar University, Bangalore-560078,, IN
2 Associate Professor, College of Pharmaceutical Sciences, Dayanandasagar University, Bengaluru-560078, IN
3 Professor and Dean, College of Pharmaceutical Sciences, Dayanandasagar University, Bengaluru-560078,, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 436-440Abstract
QbD is the heart of recent pharmaceutical development. The implementation of QbD principles delivers a cost efficient methodology for delivering quality medicines for users. Regulatory agencies like USFDA and the European medicines agency (EMA) are placing the greater importance on a part of filing. QbD is efficient advances toward progress so as to commence through pre-defined aim and emphasizes manufacturing product and quality process understanding and method control depending on resonance knowledge and quality hazard supervision. Quality cannot be tested in the products but quality should be built by design, it is an essential part of modern approaches to pharmaceutical quality.under this concept of QbD throughout designing and development of a product. It is important to define the performance profile of the desired product, the quality profile of the target product, and identify critical quality attributes.Keywords
Quality by design, Analytical method validation.References
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